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The metabolic effects of selenium are dose-dependent, and increased SELENOP levels, in particular, disrupt insulin signaling, leading to the development of insulin resistance [76, 77]

Additionally, both the molecular docking assay and the FXR-knockout assay demonstrated that Rc could activate the FXR signaling pathway, resulting in the inhibition of NF-B and subsequently reducing inflammation [253]

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10.1038/nature01960 37 HuB.LiJ.GongD.DaiY.WangP.WanL.et al (2022)

The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis