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Deficiency of B 12 make impossible to produce enough healthy RBCs (Reynolds et al., 1993)

For others, they are severe and debilitating, with labour-like cramps, heavy bleeding, diarrhoea and faintness

Briefly, after Ficoll-Paque gradient centrifugation of buffy coats, followed by dextran sedimentation of granulocytes and hypotonic lysis of erythrocytes, neutrophils were isolated to reach 99.70.2% purity (Supplementary Fig