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Studies indicate that its hepatotoxicity is closely associated with metabolic dysregulation, endoplasmic reticulum stress, and mitochondrial dysfunction

Glutathione supplementation is generally well-tolerated at typical doses (5002000 mg daily), though safety profiles differ across formulations and populations

To confirm localization of EPRS1 to Rab5-positive vesicles, we used an activation-mimic form of Rab5(Q79L)-CFP along with EPRS1-YFP and then stained activated AKT with anti-AKT Ser473 antibody to trace their location to the early endosomal membrane upon LPS stimulation (Fig

The effect remains gradual and cumulative rather than instant

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