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All data were presented as mean standard deviation (SD), analyzed using SPSS version 23.0 software and graphed using GraphPad Prism version 8 software

[By Bracken]

Science 267 , 14851488 (1995)

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route