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AC directly binds to the c-Met protein and promotes its degradation through the ubiquitinproteasome pathway, rather than affecting its mRNA levels

Therrien et al

Based on the preliminary studies, the mechanism of this organoselenium-catalysed para -selective CH bond amination is proposed in Fig

Drugs 80(4):341352

Concomitantly, we observed an increase in the senescent markers Cdkn1a and Cdkn2a in the Cyb5r3 SPCKO mouse lungs and Cyb5r3 -KD MLE12 cells, compared with WT controls, further exacerbated by bleomycin/MHV68 challenge or TGF-1 stimulation