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D-chiro-inositol is important for mediating the insulin response and has been shown to improve insulin sensitivity and improve metabolic conditions related to insulin resistance in PCOS patients

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*Correspondence: Anna Ianza, [email protected] This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This process can typically be prevented or reversed by iron chelators, such as deferoxamine (DFO), or lipid-soluble antioxidants like vitamin E ( In the current study, treatment of H1299 and A549 NSCLC cells with PA leads to a reduction in both the protein and mRNA expression levels of GPX4 and SLC7A11

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