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Description

The injected hydroxocobalamin is transported via the bloodstream to tissues throughout the body, where it acts as a cofactor for two critical enzymatic reactions: the conversion of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA

To determine whether the ASXLs binding mechanism is conserved in BRD4 ET , we tested ASXL2 EBM (aa 615-628 of ASXL2) and ASXL3 EBM (aa 10081021 of ASXL3) peptides in 1 H, 15 N HSQC titration experiments and fluorescence spectroscopy (Fig