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Brain Res 1803:148232

In mice, the loss of Acly in white adipose tissue strongly induced Acss2 expression and promoted the contribution of Acss2 to cellular acetyl-CoA pools via acetate incorporation without any discernable effect on weight 80 unless mice were fed a high-carbohydrate diet, which provoked a strong dependence on ACLY in adipocytes 106

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These results suggest that antitumor responses of CD8 + T cells are potentiated by a coordination of A2AR and the GSH/GPX4 axis