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ROS-evoked, Ca2+-dependent signalling events, such as cPKC and/or nPKC activation, seem to mediate these harmful effects

Bernhardt ML, Kong BY, Kim AM, OHalloran TV, Woodruff TK (2012) A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes

In conclusion, we describe a novel additive effect on vitamin B 12 deficiency risk for metformin exposure with a previously reported genetic risk factor in the cubilin receptor gene