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The amino acid driven alteration of diversity and composition of the GM can also be modulated by the different types of metabolites produced, including nitric oxide, ammonia, polyamines, hydrogen sulfide (H 2 S), indoles, and phenols in both the proximal and distal intestine (Dai et al., 2011

Depending on their physicochemical characteristics, dietary fibers are subdivided into insoluble and soluble dietary fibers 165

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In CRC, recent research has shown that changes in glucose, glutamine and lipid metabolism are associated with miRNA dysregulation (Table I) (91,92)

If it will not clear in plain bacteriostatic water, acetic acid water often helps