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Hence, further exploration of the impact of the gut microbiota on ferroptosis will help us gain a deeper understanding of the mechanisms underlying disease occurrence and progression, as well as strategies to delay ferroptosis

Bruno JL, Shelly EW, Quintin E-M, Rostami M, Patnaik S, Spielman D, et al

Central nervous system applications are an active growth area, with documented effects on dopamine and serotonin pathway markers, traumatic brain injury models, and spinal cord research preparations

The following specific directions are proposed to better elucidate the underlying mechanisms and assess potential risks: Conduct large-scale longitudinal cohort studies integrating exposure assessment and neurological outcomes Future research should prioritize prospective cohort studies designed to integrate detailed assessments of individual MPs/NPs exposureusing methods such as environmental monitoring, biomonitoring, and questionnaireswith longitudinal evaluation of PD progression, including relevant biomarkers, neuroimaging, and clinical symptoms

To enhance efficacy and reduce the risk of resistance, 5-FC is typically used in combination with AMB, especially in the treatment of cryptococcal meningitis (Saag et al., 2000