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Over the years, almost half of the people in the study had overdosed by accident, Lee found, not by trying to kill themselves

[DOI] [PMC free article] [PubMed] [Google Scholar] (217).Son S

Moreover, recent studies suggest that the induction of cellular senescence, rather than the promotion of apoptosis through radiotherapy or chemotherapy, might be the main mechanism for impairing the self-renewal capacity of cancer cells, particularly in the context of solid tumors [55]

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These factors can all contribute to the HIF stabilization under normoxic conditions in tumors and should be considered for future therapeutic approaches