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Another clock gene acting as a gatekeeper of inflammation is the nuclear hormone receptor REV-ERB, a known repressor of NF-B activity 57

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50 & Target [1] In Vitro SD-436 (4 day treatment) inhibits the growth of MOLM-16 leukemia cell line, SU-DHL-1 and SUP-M2 lymphoma cell lines, with IC 50 of 0.038 M (MOLM-16), 0.43 M (SU-DHL-1) and 0.39 M (SUP-M2) [1]

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( c ) We hypothesized the serum analyte with m/z = 153.0656 Da was a mixture of 2PY and 4PY