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Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included

Differences among all UA treated groups were analyzed with one-way ANOVA, Tukeys multiple comparisons test on GraphPad Prism 6 software

NAC has also been investigated in a wide range of cardiovascular conditions, with conflicting results emerging from clinical trials

While much attention has been given to the physical symptoms of menopause, such as hot flashes and osteoporosis, the neurocognitive consequences of hormonal fluctuations during the menopausal transition and the subsequent sustained estrogen loss after menopause have received less focus

References Chen, X., Zhou, Y., Peng, X