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The dysregulation of anti-inflammatory cytokines, such as interleukin-13 [50] and transforming growth factor-beta1 [51], compromises the critical balance with pro-inflammatory signals, thereby preventing the resolution of inflammation and leading to its chronic persistence

Like other antioxidants, lower ascorbate pools in the cell contribute to increase ROS that can considerably damage the photosynthetic apparatus, leading to a faster decline in photosynthetic activity in AsA-deficient tissues, thereby speed up senescence (Barth et al., It is well aasumed that ascorbate-hormone interaction plays a pivotal role in regulation of senescence (Zhang, 2013b)

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if the stress continues neurones die

MRI and voxel-based morphometry analyses have consistently demonstrated reductions in grey matter volume in key cognitive regions, including the hippocampus, prefrontal cortex, anterior cingulate cortex, and insula in patients with COPD