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Using the rotarod test to evaluate motor function in mice, systemically administered erinacine A (1 mg/kg) alleviated MPTP-induced motor coordination disruption and balance ( With respect to aspects of cognition, erinacine A improved spatial learning and memory in rodent models of AD as evidenced by a reduced escape latency in the Morris water maze task ( Molecular and cellular alterations Models and analyzed tissue In vivo studies described neuroprotective effects of erinacines and H

Several studies have shown that glutathione related enzymes like GSH S-transferase (GST) and GSSG reductase isoforms are not uniformly distributed in nuclei and cytoplasm [15]

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Test compounds were reconstituted in DMSO and added to the reaction plate.[ 3 H]-DAMGO, [ 3 H]-U69-593 or [ 3 H]-deltorphin (for -, -, and -opioid receptors respectively) was then added at a final concentration of 24 nM (Perkin Elmer, Waltham, MA, USA)