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Consistently, the naturally-occurring compound gx-50 prevented A-induced microglial activation and neuro-inflammation (IL-1, TNF, NO, COX2) in rat microglia cultures and APP transgenic mouse brain, to levels comparable with TLR4 gene silencing, and this correlated with a rescue of A-induced enhancement of TLR4 protein in vitro and in vivo (Shi et al., 2016)

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Reding R, Fair PS, Sharp CJ, Brass HJ

EPEA, N-eicosapentaenoyl-ethanolamine