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Phase Split option Daily dose 50 mg morning + 50 mg midday Notes Some sources prefer split AM dosing because the plasma half-life is short (about 4 to 7 hours in rodent PK)

However, the interactions have not been studied

Stacking multiple GLP-1 agonists together, such as semaglutide and tirzepatide, is generally not recommended due to overlapping mechanisms and increased side effect risk

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