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The GO improvement following treatment with selenium was maintained also at 12 months, suggesting that the beneficial effect of selenium is persistent after treatment withdrawal

Functional experiments confirmed that knocking down p21 expression in a DMM surgery-induced mouse OA model exacerbated articular cartilage degradation and was accompanied by a significant decrease in GPX4 protein levels in vivo , demonstrating that p21 plays an important anti-ferroptotic role in OA progression by modulating GPX4 stability (Zheng et al., 2024)

Torsional energy calculations were performed using an online torsional energy calculator 1 based on input dihedrals, which uses a combined quantum chemical ( 2 , 3 , 2 ) and empirical calculation ( 1 , 1 ) described in detail elsewhere (Haworth et al., 2010)

In patients with acute ulcerative colitis, total enteral nutrition was shown to be nutritionally effective as well as produce fewer complications compared to enteral nutrition [134]

doi: 10.1038/s41467-025-59151-0 176 PetousisSKourounisGThomakosNZografosEFountasPKarakasisKet al