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This particular step isnt invasive, barely noticeable, and can be very effective if done well

Although cigarette smoke is very complex, consisting of over 4,000 compounds linked to CVD, most studies suggest that carbon monoxide, reactive oxygen species, and nicotine are responsible for the pathogenesis of smoking-induced cardiovascular disorders ( 10 , 11 )

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Therefore, three mutually exclusive categories of individuals were created to reflect those who were susceptible, non-susceptible, and had used NPs

Countries were classified into high income countries (HICs) and low- and middle-income countries (LMICs)