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The effector of the G q/11 pathway is phospholipase C- (PLC), which catalyzes the cleavage of membrane-bound phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into the second messengers inositol (1,4,5) trisphosphate (IP 3 ) and diacylglycerol (DAG)

Another pivotal form of regulated cell death that has been documented to link to cuproptosis is ferroptosis, which is an iron-dependent cell death induced by iron accumulation and lipid peroxidation [103]

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Eventually, the GTP on the subunit is hydrolyzed to GDP, leading to the reassociation of the and subunits and the termination of signaling