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The principle of proportionality requires that anticipated collateral damage is not excessive in relation to the anticipated military advantage gained

doi: 10.3389/fmed.2016.00038

When ferroptosis inhibitors such as GLS2 and erastin were applied to P53 wild-type cells, the cells exhibited upregulated PTGS2 gene expression and underwent ferroptosis, but when P53-deficient cells were induced with GLS2 and erastin, the PTGS2 gene expression level was unchanged and ferroptosis did not occur

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