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Determination of initial turnover number The initial turnover rates were determined in PBS at pH 7.4 (8 g l 1 NaCl (Labkem, SOCH-00T), 1.44 g l 1 Na 2 HPO 4 (Supelco, 1.06586), 0.2 g l 1 KCl (Panreac, 131494) and 0.24 g l 1 KH 2 PO 4 (Fisher Scientific, BP362)) using ABTS (1 mM), DMP (5 mM), guaiacol (50 mM), sinapic acid (0.35 mM) or p -coumaric acid (0.1 mM) as substrate

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy

Statements Author contributions QW: Data curation, Investigation, Writing original draft

Early or excessive use of antibiotics can disrupt the gut microbiota, increasing the risk of diseases such as asthma and allergic rhinitis (Mitre et al., 2018)

Sigma) to give a yellow chromophore of TNB (thionitrobenzoic acid), spectrophotometrically measured at 412 nm