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mice wildtype and ApoE knockout mice were administered MC3 liposomes containing the AD-1661 siRNA composition, at 0.1, 0.03, and 0.01 mg/kg essentially as described in Example 2

YH and JZ designed the study, supervised the experiments, and revised the manuscript

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al

Furthermore, blockade of the ActRIIB pathway also results in an increase in the number of quiescent muscle stem cells, and those with strong proliferative capacity (Zhou et al., 2010)