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the most frequent adverse reactions leading to discontinuation were: nausea/vomiting (4.6%), menstrual irregularity (including vaginal hemorrhage, menorrhagia, menstrual disorder, menstruation irregular and metrorrhagia) (4.2%), fatigue (1.8%), breast tenderness (1.4%), depression (1.4%), headache (1.1%), and irritability (1.1%)

Rechargeable cigalikes can offer better long-term value and produce less waste because the battery is reused and only the pre-filled refills need replacing

Some studies link heavy marijuana use with a higher incidence of gum disease (periodontitis), which can progress to tooth loss if not managed properly

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