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While initial safety and efficacy data for radiprodil in treating GRIN-NDD GoF variants were demonstrated in the Honeycomb trial and are being further evaluated in the Phase 3 Beeline trial, emerging mechanistic evidence suggests that LoF and interminant variants may also disrupt the excitatory/inhibitory balance in neural circuits in ways that could be responsive to radiprodil modulation

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In a study published by Choi et al., the authors evaluated the effect of membrane-free stem cell extract and pyridoxal 5-phosphate treatment in A 25-35 -injected AD mice

doi: 10.1016/s1095-6433(97)00417-0

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