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However, in tumor cells, ROS-induced autophagy activation can promote cell development and cancer progression ( The Nrf2-dependent adaptive response, which includes phase II detoxifying enzymes, antioxidants, and transporters that protect cells from further carcinogenic assaults, is how chemopreventive substances or synthetic chemicals carry out their chemopreventive action

Given the involvement of the reproductive tract microbiota in modulating immune responses at the maternal-fetal interface, an exploration of the immune mechanisms behind it seems to be the next step in the program

283 In HCC, downregulation of the TGF- signaling pathway may imply loss of cancer suppressive activity, while upregulation leads to fibrosis and inflammation

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