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Prolactin activation of the long form of its cognate receptor causes increased visceral fat and obesity in males as shown in transgenic mice expressing only this receptor subtype

This sensitization leads to an augmented secretion of cytokines linked to Th1 and Th17 responses when exposed to pro-inflammatory agents ( Distinct subsets of T cells exhibit variable dependency on the biosynthesis of fatty acids, a process particularly crucial for the development of Th17 cells ( A diet rich in fats stimulates the formation of Th17 cells and enhances the activity of key enzymes in lipid metabolism, such as ACC1 ( 3.1.1 Polyunsaturated fatty acid Polyunsaturated fatty acids (PUFAs) are a beneficial class of lipids crucial for maintaining optimal human health

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Lin et al., 2012