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PloS One 8 (3), e59800

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In type 2 diabetes mellitus, portal vein insulin levels are elevated to compensate for the insulin-resistant state of the body

High levels of MMPs relate to increased cellular extravasation, angiogenesis, immune evasion, and apoptotic resistance via degradation of ECM, blood vessels, cytokines, and apoptotic factors, which result in tumour survival and metastasis (reviewed by [90])