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Notably, ALOX5 also plays a critical role by producing pro-ferroptotic 5-HpETE-PE, which amplifies inflammation and ischemiareperfusion injury (Aparoy et al

Clin Sci (Lond) 114:2735

Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH) presenting with acute fulminant hepatic failure

They used AlphaFold2 to predict the structure of the original sensor, removed the unstructured linker computationally, and reoriented Grx1 to align the GSSG binding site with the reactive cysteines of roGFP2