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doi:10.1080/13813455.2023.2258559

1, 2023, pp

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Lewandowska-Pietruszka Z., Figlerowicz M., Mazur-Melewska K

While the mechanisms that direct sortilin to each of these pathways are not well elucidated, recent work suggests that the binding of sortilin to cargo induces conformational changes that direct sortilin to specific trafficking pathways [55, 59]

Furthermore, the integration of TGF- inhibitors with novel therapeutic modalities, such as targeted delivery systems or gene therapy, could enhance treatment efficacy and specificity