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In addition to the impacts on normalizing vessel structure and function, targeting metabolism may have further benefits when combined with ICB therapies, such as reduced PD-L1 expression by tumor cells and endothelial cells when targeting glycolysis [86, 87]

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Contemporary network meta-analytical investigations have unveiled therapeutic spectrum differentiations among diverse microecological intervention modalities: prebiotics demonstrate maximal efficacy in uremic toxin elimination, achieving standardized mean differences of 1.24 for IS concentrations

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Furthermore, curcumin facilitates the migration, proliferation, and differentiation of fibroblasts, which are crucial steps in tissue remodeling and wound closure [142]