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doi: 10.1016/j.cell.2018.01.003 51 GriesserM.ShahR.Van KesselA

Thousands of published studies document its effects across multiple conditions

Banni S, Petroni A, Blasevich M, Carta G, Angioni E, Murru E, et al

It is essential for the initial transport of activated long-chain fatty acids across the mitochondrial membrane via the CPT system, thus governing the substrate flux available for both -oxidation and subsequent ketogenesis

This upregulation is not only a marker of immune cell activation, but also serves as a functional participant in the immune response, modulating cell survival, cytokine production, and peripheral immune cell migration (143, 144)