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The Primary Role of Frataxin Is in Iron-Sulfur Cluster Biosynthesis, Not in Heme While the iron storage function was disproved, frataxin was proposed to operate as an iron donor/chaperone for heme and Fe-S cluster biosynthesis

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This experience provides a critical lesson for metabolismimmunotherapy combinations: successful clinical translation requires biomarker-guided enrollment, adaptive trial design, and early verification of true target engagement [153,170]