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Ma F, Pellegrini M, "ACTINN: Automated Identification of Cell Types in Single Cell RNA Sequencing", Bioinformatics (2019)

624 The expression of iron response proteins IRP1, IRP2 and TFR was decreased, and the expression of FPN was increased, and the iron-chelating agent DFO could improve the motor phenotype and cognitive function of HD mice

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Neurological Symptoms: Involuntary Movements In rare instances, Vitamin B12 injections can lead to neurological side effects

This transporter localizes to the trans-Golgi network or late endosomes under basal conditions, but it relocalizes in a copper-dependent manner to a subapical, vesicular compartment, which facilitates both copper incorporation into ceruloplasmin and biliary copper excretion via lysosomes.180 Apart from copper, Long-Evans Cinnamon rats also have abnormal hepatic accumulation of iron.181 Chronic copper/iron accumulation in these rats leads to a 50% increase in lipid peroxidation, presumably due to copper/iron capability to induce oxidative stress by generating ROS via both mitochondrial dysfunction182 and Fenton-type, copper/iron-catalyzed Haber-Weiss reaction.183,184 These mutant rats exhibit a reduced basal bile salt-biliary excretion compared with normal, Long-Evans Agouti rats