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Circulating iron, in the form of ferric iron (Fe 3+ ) bound to transferrin, is transported into cells through the membrane-bound transferrin receptor 1 (TfR1)

Thanks to electron crystallography, it was found that proteins from the MAPEG superfamily are composed of four transmembrane helices that are grouped into trimers (21)

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Pastore A, Piemonte F, Locatelli M, Lo Russo A, Gaeta LM, Tozzi G et al

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