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The reported evidence that this pentadecapeptide is able to counteract both their over-action, and their inhibition, may suggest this pentadecapeptide as a new, but most probably essential physiological defence system and that should be further investigated

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The endocrine pathway involves interactions between metabolites and their receptors, which can induce the secretion of hormones from enteroendocrine L cells and lead to indirect signaling to the brain through systemic circulation or vagal pathways

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