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In this mini review, we give an update of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the neurodegenerative process

The specific molecular linkages between these systems and pathogenesis, on the other hand, are unknown and controversial

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Several amino acids, predominantly arginine, and proline are attacked with metal-catalyzed forces to yield glutamic semialdehyde, whereas lysine generates aminoadipic semialdehyde (Bellahcne et al., 2018)