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found that in the CIRI model, increased LDHA-mediated H3K18 lactylation modification promotes the transcription of HMGB1

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Interestingly, under this setting the NQO1 nuclear localization was reduced by EX527, a SIRT1 specific inhibitor (Fig 4D)

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EGCG decreased cellular holo-APP without changing APP mRNA quantities and inhibited the translation of a reporter gene for luciferase

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