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FIGURE 4 Action potential morphology is changed by acute application of TMAO As increasing concentrations of TMAO had a deleterious effect on the contractile recovery in the metabolic inhibition and reperfusion protocol, it was hypothesised that higher concentrations of TMAO would alter the action potential

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This calcium overload activates Tau kinases, such as GSK-3 and CDK5, thereby promoting Tau phosphorylation and exacerbating the pathological process of Alzheimers disease [117]

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Most published recommendations fall within the range of 5 to 10 mg/kg once to four times daily