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[42] [43] These properties contribute to the depletion of cysteine from respiratory chain complexes, such as Complexes I and IV, [44] since reactive oxygen species (ROS) produced by the respiratory chain can react with the cysteine residues in these complexes, leading to dysfunctional proteins and potentially contributing to aging

Oncogene 22, 73697375

In 33 human cancer cell lines, high expression of ketolytic enzymes BDH1 and OXCT1 was associated with KD resistance, as seen in HeLa xenografts where KD accelerated growth

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As non-analgesic outcomes comprise the bulk of NAC literature focus to date, the major studied perioperative indications will be assessed for strength of evidential support