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These guidelines have been periodically updated as new evidence accumulates, and are available for review at The most recently updated guidelines published October 9, 2020 highlight the Panels current recommendations about pharmacologic management of patients with COVID-19

Ideal candidates include patients with acute sports injuries seeking accelerated recovery, chronic tendinopathies that have not responded to conservative management, post-surgical orthopedic cases where optimized healing is a priority, inflammatory joint conditions where traditional treatments have fallen short, and autoimmune-mediated pain where immune modulation may provide benefit

van Die MD, Burger HG, Bone KM, Cohen MM, Teede HJ

This could be explained, at least in part, simply by the increased local concentration of RHEBGTP in the vicinity of mTORC1