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In a study with porcine kidney cells, AFB1 and deoxynivalenol showed synergistic cytotoxic effect, which suggests the importance of multiple mycotoxicosis even in farm animals as well (Zachariasova et al., 2014)

Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage

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The MM and MV groups also showed enhanced PA compared to the control group, but to a lesser extent than the MMMV group ( Figure 4A )

Factors like poor nutrition, chronic stress, exposure to environmental toxins, and illness further deplete these levels, compromising the body's ability to defend against harmful free radicals