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Epilepsy Epilepsy is a disease of the brain, the distinctive characteristic of which is a predisposition to generate unprovoked seizures 59

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This intercellular crosstalk leads to biological processes of airway inflammation, airway hyperresponsiveness, and airway remodeling that are implicated in asthma pathogenesis

Even if the main folate receptors are blocked by antibodies, leucovorin can enter the central nervous system through the reduced folate carrier (RFC) , essentially bypassing the roadblock at the FR [4]