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Another animal experiment showed reduced superoxide-dismutase (SOD) and GPX levels could be observed in the hippocampus of the SAH rat model (Sakaki et al., 1986)

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Therefore, recreational MDMA users (including those who take repeated doses in the same session) are exposed to a higher probability of relative overdose and an increased risk of suffering adverse effects from CYP2D6 substrates (Farr et al., MDMA and CYP2D6 pharmacogenetics Most research evaluating the potential impact of CYP2D6 pharmacogenetics in MDMA pharmacology has been focused on acute effects

Abdou HM, Hassan MA (2014) Protective role of omega-3 polyunsaturated fatty acid against lead acetate-induced toxicity in liver and kidney of female rats