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In the multivariate analysis, l-carnitine administration (OR 3.51, 95% CI 1.239.99, p = 0.019) and baseline NIRS data of 0.07 mMmm (OR 5.21, 95% CI 1.6916.0, p = 0.0041) were found as significant independent factors (Table 3)

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Brain Sci 9(9):239 Palma JA, Kaufmann H (2018) Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies

Therefore, it may be possible that amino acid transporters and their respective amino acids exist in a continuum of feedback loops which are dysregulated within TSC tubers, but whether that is a result of dyslamination of the cortex, altered proliferation, or reduced glial-neuron communication remains unknown