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Comparative genetic studies of primary and metastatic cancers have revealed a complex picture of metastatic evolution with diverse temporal patterns and trajectories to dissemination

doi: 10.12659/MSMBR.903910 31 XieT-XXiaZZhangNGongWHuangS

Due to insufficient oxygen supply, tumor cells are limited to metabolizing energy through anaerobic fermentation, which leads to lactic acid accumulation and the formation of an acidic tumor microenvironment (Kumari et al., 2021)