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EC 2.5.1.18) superfamily, notably members of the plant specific phi (F), tau (U), lambda (L) and dehydroascorbate reductase (DHAR) classes, as well as theta (T), zeta (Z) enzymes ( in planta as the respective proteins and show both a complex regulation and sub-cellular localization ( in vitro , we know relatively little of the function of these proteins in planta ( Arabidopsis thaliana ( At ) as a model, it has been recognized for some time that the large families of At GSTUs and At GSTFs ( At GSTF12 is involved in the regulation of anthocyanin accumulation ( At GSTU20 modulates responses to light reception ( At GSTU17 plays a regulatory role in seedling development ( In the case of At GSTF12, biochemical function can be linked to the observed phenotype of the knock-out, as inferred through metabolic profiling of the flavonoids present in the respective transparent testa 19 (TT19) mutants ( tt19 mutants, which are defective in functional At GSTF12 expression, were deficient in anthocyanin and anthocyanidin pigments, while showing elevated levels of flavonol intermediates as compared with wild type plants

10.3389/fnut.2024.1469779 279 ZhangW.LiuD.YuanM.ZhuL

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It has been demonstrated that direct butyrate administration enhances hepatic insulin signaling and decreases fat deposition in experimental models of NAFLD[127]