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Our data show that suppressing production of NADPH leaves the ER more oxidizing (or, to be more precise, more resistant to reduction) and, consequently, more resistant to an exogenous ER stressor (Gansemer et al., 2020)

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Mitochondrial p53 is apparently linked to intrinsic apoptosis signaling, so this relocalization is posited to increase susceptibility to apoptosis specifically in senescent cells