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Antioxidants 11:606

Here we report on the development and characterization of small-molecule inhibitors of GSTO1 and the use of these inhibitors to study the cellular functions of GSTO1

Conversely, in liver cancer cell lines Huh7 and Hep3B, as well as in mice with subcutaneous tumor grafts, metformin increases ROS and lipid peroxidation levels, induces ferroptosis in liver cancer cells, and enhances their sensitivity to sorafenib [223, 277]